In one human cell, two meters of DNA are tightly folded into its tiny nucleus. To achieve this feat, the genome is folded into a highly organized, complex three-dimensional structure. Our collaborators in Caltech’s Guttman lab are seeking to understand how the activity of genes are affected by their proximity to one another due to folds in the genome. 

The challenge of our collaboration was to represent the complex 3D structure of DNA, to enable scientists to explore how gene activity is affected by molecular relationships that lie within its folds.

Our team developed an interactive platform visualizing the genome in 2D and 3D that enables them to see an overview of the genome, select structures of interest and compare them at varying resolutions.